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Berkala Ilmu Kesehatan Kulit dan Kelamin

BIKK
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Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

Arjuna Subject : -

Articles 11 Documents

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Search results for , issue " Vol 27, No 1 (2015): BIKKK APRIL 2015" : 11 Documents clear

Retrospective Study of Skin Prick Test in Atopic Dermatitis Patients at DermatoVenereology Outpatient Clinic of Dr. Soetomo General Hospital Surabaya During 2007-2012 Natallya, Fransiska Rismauli; Barakbah, Jusuf
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Atopic dermatitis (AD) gives impact on quality of life of patients because ofÂ frequent exacerbation. Various factors play a role in pathogenesis of AD. Trigger factors of exacerbation especially due to enviroment including irritant and allergen agents. Identifying and avoiding trigger factors are important in management of AD. Skin prick test (SPT) is one method to detect the presence of Ig E spesiï¬c to certain allergens (food allergens, aeroallergens). Purpose: To describe the characteristic of AD patients, and evaluate the result of SPT and their clinical relevance. Methods: This research was a retrospective study of AD patients who underwent SPTÂ during 2007-2012. Results: Nineteen of 57 patients (33,3%) had positive SPT to one or more allergens, and 36 patients (63,1%) had negative result. One patient (1,8%) showed false positive result and 1 patient (1,8%) showed false negative result. The most common allergens were house dust in 8 patients (42%) and crab in 6 patients (31,6%). Clinical relevance was found in 11 patients (58%), and 8 patients (42%) had no clinical relevance. Compared with SPTânegative patients, SPTâpositive patients showed more severe symptom and clinical manifestation. Conclusions: In this study, the allergens could be detected in 19 patients (33,3%) by SPT, mostly to house dust (42%) and crab (21,6%). Clinical relevance was found in 11 patients (58%). SPT is recomended to perform in management of AD in order to detect enviromental allergen because it has signiï¬cant clinical relevance.Â Key words: atopic dermatitis, skin prick test, allergens.

Susceptibility test of Griseofulvin, Ketoconazole, Itraconazole, and Terbinafine to Dermatophyte Species Using Microdilution Method Anggarini, Dyah Ratri; Sukanto, Hari; Astari, Linda; Endraswari, Pepy Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Backgroud: Dermatophytosis is common disease in tropical countries such as Indonesia. The prevalence of dermatophytosis in general population also high (20%). The dermatophyte fungi are the etiologic agents that cause this disease, some of them had already reported to be resistant to some anti-fungi. Purpose: To determine dermatophyte species causing dermatophytosis and the resistancy of griseofulvin, ketoconazole, itraconazole, dan terbinafine to dermatophyte species. Methods: Isolates of dermatophyte from patient who met the inclusion criteria in outpatient clinic of dermato-venereology Dr. Soetomo Hospital Surabaya during October until December 2014 were analyzed with respect to their susceptibility to four anti-fungal agents (griseofulvin, ketoconazole, itraconazole, and terbinafine) using microdilution methode. Results: Thirthy patients were included in inclusion criteria, with T. mentagrophytes var. Interdigitale was the most common cause of dermatophytoses. According to MIC all 30 isolates were already resistant to all anti-fungal agent, except T. rubrum that still sensitive to ketoconazole and 80,Â itraconazole.Â Conclusion: According to MIC 16.7% isolates sensitive to griseofulvin, 23.3% to ketoconazole, 16.7% to 80 itraconazole and 20% to terbinafine.Key word: dermatophyte species, susceptibility test of anti-fungal, microdilution.

Secreted Aspartyl Proteinase[SAP] Enzyme Proï¬le on Vulvovaginalis Candidiasis Patients isolates Nugrahaeni, Diah; Agusni, Indropo; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Vulvovaginalis candidiasis (VVC) is an infection caused by various types of Candida, themost is Candida albicans. Candida produces two main enzymes that play a role in virulence, the secreted aspartyl proteinase (SAP) enzyme and the phospholipase enzyme. SAP is most widely produced by Candida albicans,which is one of the main pathogenicfactor of Candida infection. SAP is often found in cases of recurrent candidiasis vulvovaginalis (RVVC) Purpose: To evaluatethe SAP activity produced by VVC patients isolates. Methods: Descriptive observational cross-sectional study was conducted on 21 VVC patients to determine the SAP enzyme levels in VVC patients in Sexually Transmitted Infection (STI) Division, Outpatient Clinic Of Dermatology and Venerology, Dr. Soetomo General Hospital, Surabaya.Vaginal smear was examined to determine levels of SAP and culture examination to determine the kind of candida spesies that causes VVC. Results: Total subject of study are 21 patients. Twelve ofÂ 21 patients had SAP > 20 mm in diameter, 7 patients with SAP < 20 mm in diameter, and 2 patients with negative results of SAP. Fifty patients due to Candida albicans, 6 patients caused by non-albicans. Nine patients were accompanied by diabetes mellitus (DM), 1 patients by genital affection, 2 patients by condylomata acuminata. Additionally obtained in 10 patients who had previously received treatment with the results diameter SAP > 20 mm and 7 patients with of SAP diameter < 20 mm, 2 patients showed negative results of SAP. Conclusions: SAP was mainly produced by Candida albicans. SAP became more active in VVC patients that accompanied by diabetes melitus, affectiogenitalis, condylomata acuminate, and also in some patients who have received prior antifungal therapy.Key words: secreted aspartyl proteinase, vulvovaginalis candidiasis, Candida albicans,

Immunomodulators for a Variety of Viral infections of the Skin Wulan, I G A Kencana; Agusni, Indropo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: In the last decade there has been inceasing prevalence of viral infections in the world, this led to increased efforts to find a variety of new drugs and vaccines against the virus that causes. Purpose: To disccuss the provision relating to the use of immunomodulators in viral infections. Review: Some diseases caused by viruses such as varicella, herpes zoster, herpes simplex, condyloma acuminata, molluscum contagiosum and Human immunodeficiency syndrome (HIV). Immunomodulator also known as biological response modifier, a wide variety of materials imunoaugmentor is either recombinant, synthetic, or natural medicines that returns an imbalance of the immune system that is used in immunotherapy. Immunotherapy is a treatment approach by restoring, enhancing, or suppresing the immune response. Immunomodulator administration on viral infections gave varying results. Conclusion: Immunomodulatory regimens on viral infections is an attractive therapeutic approach, because the side effects are often lighter than the side effects of drugs that have been there, in addition to the more rarely cause resistance to treatment of diseases caused by viral infection.Key word: viral infection, immunomodulator, immune response.

Viral infection proï¬le in Pediatric Dermatology Division clinic of Dermatology and Venereology Outpatient Dr. Soetomo General Hospital Surabaya Prabawaningrum, Kinanti; Zulkarnain, Iskandar
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Viral infections are common in children and distributed widely in the world. There are not many studies that discuss the proï¬le of viral infection in children in East Java. Purpose: To evaluate viral infections patients proï¬les in the Pediatric Dermatology Division Dermatovenereology Outpatient Clinic of Dr. Soetomo General Hospital in 2008-2010 including prevalence, demographic data, type of infection, patient complaints, skin lesions and management. Methods: A retrospective study using medical records for the period January 2008-December 2010. Basic data (age , gender), history (chief complaint, began to arise, disease history), examination (morphology) and treatment (therapy, repeat visits) were recorded. Results: Viral infection patients as much as 285 patients (6.5 % of all pediatric patients at URJ). Most found diagnosis is molluscum contagiosum (40.4%), in the age group 5-14 years (68.4 %), highest complaints pimples (42.8 %) , most duration of diseases >10 days (40 %). Most management actions in the cosmetics division (61.1 %). Conclusion: Viral infection patients in Pediatric Dermatology Division clinic of Dermatology and Venereology Outpatient Dr. Soetomo General Hospital Surabaya in 2008-2010 is likely to increase each year and require a more comprehensive management.Key words : viral infection, child, RSUD Dr. Soetomo.

Pure Neural Leprosy Verdy, Verdy; Budiyanto, Arief; Siswati, Agnes Sri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Pure neural leprosy (PNL) is an infection by Mycobacterium leprae with clinical manifestation as nerve thickening, sensory nerve impairment, with or without motoric nerve involvement, and without skin lesion. Pure neural leprosy causes progressive degeneration of nerve function. Diagnosis establishement of PNL is difficult. Purpose: To discuss about PNL especifically in aspects of the diagnosis and therapy. Reviews: Gold standard in diagnosis of PNL is histopathological examination from nerve biopsy but this procedure is still difficult for various reasons. Some investigations can be done for PNL such as cytological fine needle aspiration, Mitsuda test, serology test for antibody anti-PGL1, electroneuromyography (ENMG), and polymerase chain reaction (PCR). Pure neural leprosy classification is based on findings of abnormality in neurological, immunological, and histopathological. Pure neural leprosy therapy is based on the classification of paucibacillary or multibacillary. Conclusions: The clinical and epidemiological findings plus with the electroneuromyography alteration were finally accepted as sufficient criteria to diagnose PNL. Pure neural leprosy therapy follows WHO regiment in accordance with the paucibacillary or multibacillary classification.Key words: pure neural leprosy, Mycobacterium leprae, nerve biopsy, anti-PGL-1, electroneuromyography.

The Profile of Erysipelas and Cellulitis Patients Novarina, Ryski Meilia; Sawitri, Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Erysipelas and cellulitis are acute infectious serious skin diseases, due to the entry of bacteria through the unintact skin barrier and can be fatal. Purpose: To determine the clinical manifestation and management of hospitalized erysipelas and cellulitis patients at the dermatolovenerology inpatient Dr. Soetomo General Hospital in period of 2008-2011. Methods: The study was conducted retrospectively based on the medical records of the hospitalized patients include case number, gender, age, main complaint and duration, trigger factors, concomitant factors that can be as the underlying disease, lesion site, laboratory examinations, treatments, length of treatment associated with Erythrocyte Sedimentation Rate (ESR) and the prognosis. Results: The erysipelas and cellulitis cases were 65 cases (1.9%) of the total hospitalized cases of skin diseases, with the number of men and women were 36 and 29 patient, respectively. The highest age group were 45-65 years (35.4%). Main complaint was swelling, redness and pain (66,2%) and the duration of complaints 1-7 days (81.5%), Most triggering factors due to scratching (34%). Anemia (30,8%) is the most underlying disease. The majority of lesion sites are in the lower extremities in 56 patients (86.1%). Laboratory tests showed anemic (30.8%), leukocytosis (44.6%) and (76.9%) ESR > 20mm/h (76.9%). The specimen of the lesion of 18 cases were cultured, there were found majority bacterial were Staphylococcus aureus (37.5%). The managements of treatment of 25 cases (38.5%) were consisted: immobilization, intravenous injection of Ampicillin and wet dressing with normal saline, 15 cases with ESR>50mm/h were treated for 8 -14days. The complications (gangrenosum cellulitis) were found in 1 case (1,5%), and 40 patients (61.5%) discharge from hospital in a recovery state. Conclusion: The management of patients with erysipelas and cellulitis had been appropriate based on the diagnosis and treatment guidelines. Staphylococcus aureus is the most frequent bacteria found in culture.Key words: erysipelas, cellulitis, Staphylococcus aureus.

Successful Treatment of Actinomycetoma with Combination of Cotrimoxazole and Tetracycline Verdy, Verdy; Dewi, Vina Ajeng Puspa; Budiyanto, Arief; Siswati, Agnes Sri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Actinomycetoma is an infection of chronic granulomatous disease on the skin, subcutaneous tissue, fascia, and bone, occured after trauma because of bacteria innoculation. Clinical features seem painless nodules, abscess, fistula, and sinusÂ with granulated discharge.Gold standard treatment for actinomycetoma is cotrimoxazole. Combination therapy with other antibiotic is needed to prevent resistance and improve therapeutic efficacy. Purpose: To discuss successful treatment of actinomycetoma with combination of cotrimoxazole and tetracycline Case: A 19-years-old woman had complained ofÂ chronic post-traumatic wounds since two years ago. Dermatological examination showed multiple painless nodules, sinus, and discharge on right dorsum pedis. Histopathological examination demonstrated sinus in dermis, suppurative granulomas, and SplendoreHoeppli phenomenon in dermis layer. Case Management: Combination therapy consist of cotrimoxazole 2x960 mg, that was given for 6 months and tetracycline 4x500 mg, that was given in the first 1 month.Â No side effects and drug allergy during and/or post treatment was found. After clinical evaluation for 6 months, successful of treatmentÂ was obtained and no recurrence was found. Conclusion: The combination therapy of cotrimoxazole for 6 months and tetracycline for 1 month was proven to be effective and no recurrence was found.Key words: actinomycetoma, cotrimoxazole, tetracycline.

Profile of Scabies in Children Paramita, Kartika; Sawitri, Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Scabies is a common parasitic infestation of the skin caused by Sarcoptes scabiei. Scabies is a common public health problem that occurs throughout the world with an estimated prevalence of 300 million individuals. Factors that lead to the high prevalence of scabies include high humidity, lack of sanitation, overcrowding, malnutrition, poor personal hygiene, knowledge, attitude, and behaviour of less supportive healthy lifestyle. Although scabies is not fatal or life-threatening, but the disease can be severe and persistent, which may lead to weakness and secondary skin infections. Purpose: To evaluate the clinical presentation, diagnosis, and treatment of scabies in children at Dermatovenereology outpatient clinic of Dr. Soetomo General Hospital Surabaya. Methods: A retrospective study within 2009 to 2011 using medical record of new patients, aged < 14 years old. Results: The total patients of scabies were 282 patients (5,9% of all pediatric patients in outpatient clinic). Most common group of age was 5-14 years old with the total 180 patients (63,8%), the majority of complaint was itching at night (90,1%), the most frequent location of the lesions was in the web of the fingers and the most common source of transmission is the patients familyÂ (51,4%). The most given topical scabisid was Permethrin cream 5% (97,3%). Conclusions: The diagnosis of scabies could be established by anamnesis and physical examination. Patients education is needed to reduce the reinfection and cut the source of transmission.Key words: scabies, children, Sarcoptes scabiei, retrospective study.

Management of Drug Eruption in Dermatovenereology Ward of Dr. Soetomo General Hospital Surabaya: Retrospective Study Anggarini, Dyah Ratri; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background:Â Drug eruption is a skin alteration with or without the involvement of other organ, which appeared after administration of drug at dose used for prevention, diagnosis, or treatment. The mechanism divided into 2 groups, which are type A (can be predicted) and type B (can not be predicted). Purpose:Â To evaluate the management of drug eruption in Dermatovenereology Ward at Dr. Soetomo General Hospital Surabaya. Methods: Retrospective study of drug eruptions patients was performed based on medical records within 2009-2011. Basic data, history of allergies, previous medical history, suspected drugs, diagnosis, and previous treatment were recorded. Results: The largest age group is 25-44 years, ratio of women and men is 1.4: 1, most suspected drugs as the cause of the eruption were paracetamol (59), amoxicillin (23), cefadroxil (17). Most common diagnosis was Steven-Johnson syndrome (SJS) as many as 23.4%, the most widely used treatment was steroids, and the average treatment duration was 10 days. Drug patch test (DPT) was conducted to determine the exact cause of drug eruption as the follow up. Conclusion: Drug eruptions can occur in varying degrees, potential to recur, and life-threatening thus appropriate treatment to prevent it is required. Management included given treatment, patient education regarding drug eruption causes, type of eruption, and DPT to determine the cause of drug eruption.Key words: drug eruptions, management, drug patch test (DPT), retrospective study.

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